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Jeffrey H Grubb Selected Research

Mucopolysaccharidosis VII (Sly Syndrome)

1/2020Vestronidase alfa: Recombinant human β-glucuronidase as an enzyme replacement therapy for MPS VII.
10/2012Biochemical evidence for superior correction of neuronal storage by chemically modified enzyme in murine mucopolysaccharidosis VII.
9/2012Long circulating enzyme replacement therapy rescues bone pathology in mucopolysaccharidosis VII murine model.
4/2010New strategies for enzyme replacement therapy for lysosomal storage diseases.
4/2009Mutations and polymorphisms in GUSB gene in mucopolysaccharidosis VII (Sly Syndrome).
6/2008Infused Fc-tagged beta-glucuronidase crosses the placenta and produces clearance of storage in utero in mucopolysaccharidosis VII mice.
6/2008Acidic amino acid tag enhances response to enzyme replacement in mucopolysaccharidosis type VII mice.
2/2008Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.
7/2007Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor.
10/2006Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors.
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Jeffrey H Grubb Research Topics

Disease

15Mucopolysaccharidosis VII (Sly Syndrome)
01/2020 - 11/2002
14Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/2020 - 05/2003
9Mucopolysaccharidoses
03/2013 - 12/2003
4Mucopolysaccharidosis IV (Morquio Syndrome)
05/2007 - 12/2003
2Mucopolysaccharidosis III (Sanfilippo Syndrome)
10/2012 - 07/2008
2Hemochromatosis (Bronze Diabetes)
06/2008 - 03/2002
1Mucopolysaccharidosis I (Hurler Syndrome)
03/2013
1Developmental Bone Diseases (Bone Dysplasia)
03/2013
1Edema (Dropsy)
06/2008
1Gaucher Disease (Gaucher's Disease)
10/2006
1Hypophosphatasia
07/2006

Drug/Important Bio-Agent (IBA)

16EnzymesIBA
01/2020 - 12/2003
12GlucuronidaseIBA
01/2020 - 11/2002
5GlycosaminoglycansIBA
03/2013 - 08/2004
3Keratan SulfateIBA
03/2013 - 12/2003
3SulfatasesIBA
05/2007 - 12/2003
2N-sulfoglucosamine sulfohydrolase (sulfamidase)IBA
10/2012 - 07/2008
2IronIBA
06/2008 - 03/2002
1Heparitin Sulfate (Heparan Sulfate)IBA
03/2013
1Biomarkers (Surrogate Marker)IBA
03/2013
1CarbohydratesIBA
10/2012
1PerT-GUSIBA
10/2012
1Lysergic Acid Diethylamide (LSD)IBA
07/2008
1Hormones (Hormone)IBA
06/2008
1OligopeptidesIBA
06/2008
1Transferrin Receptors (Transferrin Receptor)IBA
06/2008
1HepcidinsIBA
06/2008
1Acidic Amino AcidsIBA
06/2008
1Mannose (D-Mannose)IBA
10/2006
1Mannose ReceptorIBA
10/2006
1diphosphoric acid (pyrophosphoric acid)IBA
07/2006
1Alkaline PhosphataseIBA
07/2006
1human GALNS proteinIBA
11/2005
1CreatinineIBA
04/2004
1Peptides (Polypeptides)IBA
03/2004
1Proteins (Proteins, Gene)FDA Link
03/2002
1Transferrin (beta 2 Transferrin)IBA
03/2002

Therapy/Procedure

10Enzyme Replacement Therapy
01/2020 - 03/2004
1Enzyme Therapy
10/2006
1Therapeutics
11/2005